Thermosensitive Hydrogels from Copolymers ofN-Isopropylacrylamide and Anionic Monomers

Hydrogels are the promising classes of polymeric drug delivery systems with the controlled release rates. Among them, injectable thermosensitive hydrogels with transition temperature around the body temperature have been wildly considered. Chitosan is one of the most abundant natural polymers, and its biocompatibility and biodegradability makes it a favorable thermosensitive hydrogel that has been attracted much attention in biomedical field worldwide. In this work, a thermosensitive and injectable hydrogel was prepared using chitosan and β-glycerophosphate (β-GP) incorporated with an antibacterial drug (gentamycin). This drug loaded hydrogel is liquid at room temperature, and becomes more solidified gel when heated to the body temperature. Adding β-GP into chitosan and drug molecules and heating the overall solution makes the whole homogenous liquid into gel through a 3D network formation. The gelation time was found to be a function of temperature and concentration of β-GP. This thermosensitive chitosan based hydrogel system was characterized using FTIR and visual observation to determine the chemical structure and morphology. The results confirmed that chitosan/(β-GP) hydrogels could be a promising controlled-release drug delivery system for many deadly diseases.

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Mechanical properties, degradation kinetics and cytocompatibility of photopolymerized thermosensitive hydrogels for tissue engineering applications

Journal of Controlled Release ◽

10.1016/j.jconrel.2008.09.034 ◽

2008 ◽

Vol 132 (3) ◽

pp. e50-e51 ◽

Cited By ~ 1

Author(s):

T. Vermonden ◽

N.E. Fedorovich ◽

D. van Geemen ◽

J. Alblas ◽

C.F. van Nostrum ◽

...

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Degradation Kinetics ◽

Engineering Applications ◽

Thermosensitive Hydrogels

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Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

10.26434/chemrxiv.14472114.v1 ◽

2021 ◽

Author(s):

Malik Salman Haider ◽

Taufiq Ahmad ◽

Mengshi Yang ◽

Chen Hu ◽

Lukas Hahn ◽

...

Keyword(s):

Drug Delivery ◽

Stem Cells ◽

Gel Strength ◽

Adipose Derived Stem Cells ◽

3D Bioprinting ◽

Thermosensitive Hydrogel ◽

Clay Nanoparticles ◽

Hydrogel Matrix ◽

Thermosensitive Hydrogels ◽

3D Printed

As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning and rapid recovery after stress. Addition of clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to the hydrogel matrix, which remained fully viable after printing. Therefore, the presented materials adds to the available material toolbox for 3D bioprinting. <br>

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Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel: A dual approach for in situ treatment of tumors

Asian Journal of Pharmaceutical Sciences ◽

10.1016/j.ajps.2018.05.004 ◽

2018 ◽

Vol 13 (4) ◽

pp. 373-382 ◽

Cited By ~ 8

Author(s):

Meng Xu ◽

Yanhua Mou ◽

Mingming Hu ◽

Wenxiang Dong ◽

Xitong Su ◽

...

Keyword(s):

Controlled Release ◽

Dual Approach ◽

Thermosensitive Hydrogels ◽

Intratumoral Delivery

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Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis

Therapeutic Delivery ◽

10.4155/tde-2020-0090 ◽

2020 ◽

Vol 11 (12) ◽

pp. 779-790

Author(s):

Analía I Romero ◽

Alicia G Cid ◽

Nicolás E Minetti ◽

Cintia A Briones Nieva ◽

María F García Bustos ◽

...

Keyword(s):

Cutaneous Leishmaniasis ◽

Complex Viscosity ◽

The Body ◽

Neglected Tropical Disease ◽

Lumped Model ◽

Valuable Alternative ◽

Gelling Temperature ◽

Alternative Systems ◽

Thermosensitive Hydrogels ◽

Cutaneous Form

Background: Leishmaniasis is a neglected tropical disease and its cutaneous form manifests as ulcers or nodules, generally in exposed parts of the body. This work aimed to develop ivermectin (IVM) thermosensitive hydrogels as topical formulations to improve cutaneous leishmaniasis treatment. Materials & methods: Hydrogels based on poloxamers 407 and 188 with different concentrations of IVM were prepared and rheologically characterized. The IVM release profiles were obtained and mathematically analyzed using the Lumped model. Results: The formulation containing 1.5% w/w of IVM presented an adequate gelling temperature, an optimal complex viscosity and elastic modulus. Hydrogels allowed to modulate the release of IVM. Conclusion: IVM thermosensitive hydrogels can be considered a valuable alternative to improve the treatment of cutaneous leishmaniasis.

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